منابع مشابه
[Therapy of systemic sclerosis].
The treatment of the patient with systemic sclerosis has greatly improved in the last ten years, because of two kinds of achievements. A number of drugs have been demonstrated to be active in some disease manifestations like alveolitis, pulmonary hypertension and complicated Raynaud's phenomenon. Some of these drugs namely cyclophosphamide and iloprost await to be confirmed as disease modifying...
متن کاملTargeted Therapy in Systemic Sclerosis
Targeted therapies use an understanding of the pathophysiology of a disease in an individual patient. Although targeted therapy for systemic sclerosis (SSc, scleroderma) has not yet reached the level of patient-specific treatments, recent developments in the understanding of the global pathophysiology of the disease have led to new treatments based on the cells and pathways that have been shown...
متن کاملMolecular targets for therapy in systemic sclerosis
Despite significant advances have been made in the recent years regarding organ-specific therapies, there is no approved 'disease-modifying' antifibrotic drug for systemic sclerosis (SSc) available to date. Although non-selective immunosuppressive agents are routinely used to treat patients with SSc, large well-controlled studies are lacking for almost all immunosuppressive agents and further e...
متن کاملSystemic sclerosis: from pathogenesis to targeted therapy.
Systemic sclerosis (scleroderma) leads to morbidity and mortality through a combination of inflammation, fibrosis and vascular damage leading to internal organ complications affecting the heart, lung, kidneys and bowel. More than half of those diagnosed ultimately die from the disease. Current treatments focus on broad spectrum immunosuppression or organ-based therapy for complication such as l...
متن کاملSystemic sclerosis and dexamethasone cyclophosphamide pulse therapy.
Sir, There have been quite a few instances where the physician or may be even a dermatologist (mis) advices a patient having systemic sclerosis that there is no satisfactory treatment for this disease, as has also been done in the paper Therapeutic trials for systemic sclerosis: An update by Sardana and Garg.[1] Such patients often feel frustrated and disappointed, till another dermatologist ...
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ژورنال
عنوان ژورنال: Reumatismo
سال: 2011
ISSN: 2240-2683,0048-7449
DOI: 10.4081/reumatismo.2004.1